OUR GROUP
OUR GROUP
Senior Lecturer, Research Associate
Our research involves searching for new treatments and detection methods for CNS diseases, like frontotemporal dementia, amyotrophic lateral sclerosis, autism spectrum disorder and disorders involving neuroinflammation. We use techniques such as tissue culture, iPSCs, transfection, cellular assays, immunohistochemistry, radioligand binding, PCR, sequencing and western blots to find new drug targets and therapeutics for these diseases.
MedChem Australia and Associate Lecturer in Chemistry
Andrew completed his PhD under the supervision of Prof. Danielle Skropeta and Prof. Haibo Yu at the University of Wollongong in 2019. Later that year, he joined Michael's research group as a Centre for Drug Discovery Innovation Postdoctoral Fellow (2019-2024). As part of this fellowship Andrew's research focussed on small molecule synthesis and computational studies for a variety of CNS drug discovery projects. Andrew is currently an Associate Lecturer in the University of Sydney's School of Chemistry (2023-prsent) and a Postdoctoral Fellow with MedChem Australia (2025-present).
Industry affiliated Postdoctoral Researcher
Wendy was awarded a PhD in organic chemistry from the University of Sydney in 2021. Her research was focused on the design and synthesis of bioactive natural products and derivatives as novel anti infectives. At Kinoxis, Wendy strives to develop the first selective small molecule PET tracer for the oxytocin receptor which will be instrumental for further development of the Kinoxis pipeline.
Industry affiliated Postdoctoral Researcher
Post-doctoral Fellow
Sasha majored in Pharmacology while completing her Bachelor of Medical Science at USYD. This exposure made her realise her passion for Pharmacology – specifically the drug design aspect – and led her to approach Prof Michael Kassiou with interest in an Honours project under his supervision. Her Honours project focused on drug design for targeting the oxytocin signalling pathway as an avenue for therapeutics to treat social disorders. This opportunity allowed her to experience working in a lab-based research environment with some of the most gifted people she knows. Sasha enjoyed this process immensely, thus deciding to further pursue this career path by beginning her PhD under the supervision of Dr Eryn Werry and Prof Michael Kassiou, with a focus on drug design in neurodegeneration. She completed her PhD
Postdoctoral Research Fellow (MedChem Australia)
Associate Lecturer (Teaching and Research) Sydney Pharmacy School
Associate Lecturer (Teaching and Research) Sydney Pharmacy School
Investigation of novel purinergic therapeutics for the treatment of Alzheimer’s disease and amyotrophic lateral sclerosis
Alzheimer’s Disease and Amyotrophic Lateral Sclerosis are two neurodegenerative diseases that have a significant health and economic burdens. Current treatments fail to significantly treat disease progression and only alleviate minor symptoms within each disease, respectively. Therefore, there is a need for the identification and design of novel therapeutic targets. This project will explore the design of novel purinergic therapeutics at antagonising the purinergic receptors investigated using high throughput methods. Furthermore, the project will develop a disease relevant assay for screening therapeutics using induced pluripotent stem cell derived microglia and astrocytes to identify lead compounds based of rational drug design. Techniques will include fluorescence and luminescence assays as well as western blotting.
P2X7 Antagonists and Their Role in Inflammation
Chronic inflammation has been proven to play a major role in advancing the pathologies of both neurodegenerative and cardiac diseases. The P2X7 receptor plays a prolific role in the pro-inflammatory signalling cascade, making P2X7 antagonism a promising approach for the development of anti-inflammatory therapies. My project aims to elucidate key structure activity relationships of small molecule antagonists and novel pharmacophores for the P2X7 receptor.
Drug development for neurodegenerative disease is hindered by current pre-clinical animal and cellular models which do not recapitulate the genetic and pathophysiological complexity of these conditions. Using 3D bioprinting technology and induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS), my project aims to develop several in vitro multicellular models of nervous system tissue. These will serve as a screening platform to identify novel drug candidates.
Design and Synthesis of AUTAC's Targeting TDP-43 Pathlology
Autophagy-targeting chimeras (AUTACs) are therapeutic molecules that harness the autophagy degradation system to selectively degrade intracellular targets. Each AUTAC is comprised of two parts: a warhead to provide target selectivity, linked to a degradation tag that recruits an autophagosome. For my honours project, I am attempting to synthesise novel AUTACs for the targeted degradation of TDP-43 protein inclusions, which are a key characteristic of frontotemporal dementia pathophysiology.
Optimisation and Synthesis of P2X7 Receptor Antagonists
Accumulating evidence has implicated P2X7-mediated cytokine signaling in chronic pain, neurodegenerative conditions (e.g. Alzheimer's, Parkinson's) and neuropsychiatric disorders. Clinical translation of P2X7R antagonists has remained elusive despite persistent research efforts to optimise PK/PD properties of small molecule candidates. My project aims to address key barriers to therapeutic development by exploring novel P2X7 antagonist chemotypes and characterising their structure-activity relations.
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+61 2 9351 2745
michael.kassiou@sydney.edu.au
The University of Sydney
School of Chemistry F11 | NSW | 2006