OUR GROUP
OUR GROUP
Senior Lecturer, Research Associate
Our research involves searching for new treatments and detection methods for CNS diseases, like frontotemporal dementia, amyotrophic lateral sclerosis, autism spectrum disorder and disorders involving neuroinflammation. We use techniques such as tissue culture, iPSCs, transfection, cellular assays, immunohistochemistry, radioligand binding, PCR, sequencing and western blots to find new drug targets and therapeutics for these diseases.
Postdoctoral Research Associate (MedChem Australia)
Andrew completed his PhD under the supervision of Prof. Danielle Skropeta and Prof. Haibo Yu at the University of Wollongong in 2019. Later that year, he joined Michael's research group as a Centre for Drug Discovery Innovation Postdoctoral Fellow (2019-2024). As part of this fellowship Andrew's research focussed on small molecule synthesis and computational studies for a variety of CNS drug discovery projects. He was an Associate Lecturer in the University of Sydney's School of Chemistry (2023-2025). Andrew is currently a Postdoctoral Fellow with MedChem Australia (2025-present).
Postdoctoral Research Associate (MedChem Australia)
Postdoctoral Research Associate (MedChem Australia)
Postdoctoral Research Fellow
Sasha majored in Pharmacology while completing her Bachelor of Medical Science at USYD. This exposure made her realise her passion for Pharmacology – specifically the drug design aspect – and led her to approach Prof Michael Kassiou with interest in an Honours project under his supervision. Her Honours project focused on drug design for targeting the oxytocin signalling pathway as an avenue for therapeutics to treat social disorders. This opportunity allowed her to experience working in a lab-based research environment with some of the most gifted people she knows. Sasha enjoyed this process immensely, thus deciding to further pursue this career path by beginning her PhD under the supervision of Dr Eryn Werry and Prof Michael Kassiou, with a focus on drug design in neurodegeneration. She completed her PhD
Postdoctoral Research Associate
Postdoctoral Research Associate (MedChem Australia)
Postdoctoral Research Associate (MedChem Australia)
if he ever replies to us
Drug development for neurodegenerative disease is hindered by current pre-clinical animal and cellular models which do not recapitulate the genetic and pathophysiological complexity of these conditions. Using 3D bioprinting technology and induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS), my project aims to develop several in vitro multicellular models of nervous system tissue. These will serve as a screening platform to identify novel drug candidates.
Design and Synthesis of AUTAC's Targeting TDP-43 Pathlology
Autophagy-targeting chimeras (AUTACs) are therapeutic molecules that harness the autophagy degradation system to selectively degrade intracellular targets. Each AUTAC is comprised of two parts: a warhead to provide target selectivity, linked to a degradation tag that recruits an autophagosome. For my honours project, I am attempting to synthesise novel AUTACs for the targeted degradation of TDP-43 protein inclusions, which are a key characteristic of frontotemporal dementia pathophysiology.
Cellular senescence is a physiological state cells enter in response to various cellular stressors. Despite being a normal physiological process, senescence in the context of neurodegenerative diseases can lead to chronic inflammation and loss of functionality, exacerbating neurodegeneration. My project aims to explore small molecule therapeutics to target these senescent cells, reducing their inflammatory burden and slowing disease progression.
Arginine vasopressin (AVP) receptors represent a promising target for the treatment of mental disorder. Activation of vasopressin receptor 1a (V1aR) has been shown to promote anxiogenic and depressive-like behaviours and is associated with negative changes in social behaviour. This project aims to develop V1a receptor antagonists and explore their potential as treatments for neuropsychiatric disorders.
P2X7R Antagonists
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+61 2 9351 2745
michael.kassiou@sydney.edu.au
The University of Sydney
School of Chemistry F11 | NSW | 2006